Preparation of a 20(R)-Ginsenoside $Rh_2$ and the 20(S) Epimer from Protopanaxadiol Saponins of Panax ginseng C.A. Meyer

인삼의 Protopanaxadiol계 사포닌으로부터 20(R)-Ginsenoside $Rh_2$ 및 20(S) 이성체의 제조

  • 김신일 (한국인삼연초연구소 인삼효능부) ;
  • 백남인 (한국인삼연초연구소 인삼효능부) ;
  • 김동선 (충남대학교 자연과학대학 생화학과) ;
  • 이유희 (한국인삼연초연구소 인삼효능부) ;
  • 강규상 (한국인삼연초연구소 인삼효능부) ;
  • 박종대 (한국인삼연초연구소 인삼효능부)
  • Published : 1991.10.01

Abstract

A mixture of 20(R)- and 20(S)-ginsenoside Rg$_{3}$ was obtained under mild acidic hydrolysis from protopanaxadiol saponins, ginsenosides Rb$_{1}$, Rb$_{2}$, Rc and Rd. The product was acetylated to give the peracetates, which were further converted into 20(R)-ginsenoside Rg$_{3}$, 20(S)-ginsenoside Rg$_{3}$, 20(R)-ginsenoside Rh$_{2}$ and 20(S)-ginsenoside Rh$_{2}$ by the direct alkaline treatment depending upon two kinds of temperature conditions respectively. The structure and physicochemical properties of a prosapogenin, 20(R)-ginsenoside Rh$_{2}$, were investigated.