Prenatal Development of Gonadotropin Releasing Hormone (GnRH) Neurons in the Rat Brain

흰쥐 태아 뇌에서 GnRH 신경세포의 초기발생과정

  • 이영기 (서울대학교 분자생물학과) ;
  • 최완성 (서울대학교 분자생물학과 경상대의대 해부학과 서울대 의대 해부학과)
  • Published : 1991.10.01


The present experiment was carried out 1) to study the developmental topography of GnRH neuronal system and 2) to characterize the cellular localization of GnRH neurons in the prenatal brain development of the rat. At embryonic day (I) 14.5, immunoreactive cell bodies of GnRH were first seen in the nasal septum and in the ganglion terminate located in the ventral protion of the caudal olfactory bulb. Two days later (E 16.5), GnRH-containing neurons were observed at the level of olfactory tubercle and diagonal band of Broca, which is the first appearance in the intracerebral region. From 118.5, the topographic pattern of immunoreactive GnRH perikarya was similar to that of adult rats. The present data suggest that GnRH neurons were originated from the nasal septum and gradually extended to the hvpothalamic regions with increasing fetal age.