Effect of dietary vitamin E on the lipid peroxidation by dietary iron injected to male rats

Vitamin E가 철분 투여로 인한 rat의 지질 과산화에 미치는 영향

  • Huh, Rhin-sou (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Young-hong (College of Veterinary Medicine, Kyungpook National University) ;
  • Do, Jae-cheul (College of Veterinary Medicine, Kyungpook National University) ;
  • Choi, Yeon-shik (College of Veterinary Medicine, Kyungpook National University) ;
  • Cheong, Cheong-won (College of Veterinary Medicine, Kyungpook National University)
  • 허린수 (경북대학교 수의과대학) ;
  • 김영홍 (경북대학교 수의과대학) ;
  • 도재철 (경북대학교 수의과대학) ;
  • 최연식 (경북대학교 수의과대학) ;
  • 정정원 (경북대학교 수의과대학)
  • Received : 1991.05.02
  • Published : 1991.07.31

Abstract

This study was designed to investigate the effect of dietary vitamin E on the lipid peroxidation by dietary iron-injected to male rats. Sprague-Dawely strain male rats were divided into three experimental groups, namely control, iron injected and iron-vitamin E injected groups. The control group was fed with normal diet; the iron injected group was given normal diet and while injected intraperitoneally 30mg of ferric hydroxide/100g of body weight 20 times every 3 days. The iron-vitamin E injected group was intraperitoneally administered 30mg of ferric hydroxide/100g of body weight 20 times every 3 days and vitamin E every day with the dose of 5IU(5mg)/100g body weight. All experimental groups were maintained for 60 days with feeding on the respective ratio. The results obtained from this experiment were summarized as following: 1. The net weight gain was significantly decreased by the iron injection, but much increased by the vitamin E injection. 2. The contents of unsaturated fatty acid in phospholipid in liver, kidney, muscle and serum were decreased by the iron injection, but increased by the vitamin E injection. 3. The increment of malondialdehyde contents was induced by the iron overloading, but significantly decreased by the vitamin E injection. Therefore, it is suggested that dietary iron administration to male rats facilitates the lipid peroxidation in vivo and vitamin E has the inhibiting effect on lipip peroxidation process by iron.