Effects of Ursolic Acid Isolated from Eriobotrya Japonica on c-myc and c-Ha-ras Oncogene Expression at Sarcoma 180 cell

Sarcoma 180 세포에서 비파엽에서 분리한 올솔레산이 c-myc 과 c-Ha-ras 암유전자 발현에 미치는 영향

  • Yang-Ae Choi (Department of Biology, Food Science Pusan National University) ;
  • Tae Hyong Rhew (Department of Biology, Food Science Pusan National University) ;
  • Kun-Young Park (Departments of Biology , Food Science Nutrition , Pusan National University) ;
  • Hae-Young Chung (Department of Biology , Food Science and Pharmacy, Pusan National University) ;
  • Jae-Chung Hah (Department of Biology, Food Science Pusan National University)
  • Published : 1992.06.01

Abstract

The sarcoma 180 cells were treated with ursolic acid which was previously extracted from leaves of Eriobotrya japonica Lindy (Rosaceae) and identified as a potent anticarinogenic agent. Suppressing effects of the compounds with testing changes in selected oncogenes expression were examined by using the northern hybridization method. Ursolic acid significantly suppressed c-myc oncogene expression. However, c-ha-ras oncogene expression was lowered slightly with the ursolic acid treatment. Therefore, it was concluded that preproven anticarcinogenic effects of ursolic acid should be partly ascribed to the modified oncogenic expression.