Effects of Dietary Coenzyme Q_{10}$ and Vitamin E on Hepatic Lipid Metabolism in Adriamycin-Treated Rat

식이 중에 첨가한 Coenzyme $Q_{10}$가 Vitamin E가 Adriamycin을 투여한 흰쥐의 간 지질대사에 미치는 영향

  • 양경미 (영남대학교 식품영양학과) ;
  • 정영아 (영남대학교 식품영양학과) ;
  • 서정숙 (영남대학교 식품영양학과)
  • Published : 1992.10.01

Abstract

The present study was designed to evaluate the effects of dietary coenzyme $Q_{10}$ and vitamin E on hepatic lipid metabolism changes in adriamy cin(ADR)-treated rats. ADR treatment significantly increased the plasma levels of lipid peroxide in rats. But this increase was reduced by dietary supplementation of coenzyme $Q_{10}$ or vitamin E. Catalase and glutathione peroxidase activities were not greatly changed by ADR treatment, but the activities were significantly increased by dietary coenzyme $Q_{10}$. There was a tendency of lower superoxide dismutase activity in ADR-treated rats. However, coenzyme $Q_{10}$ administration induced this enzyme activity. The contents of cholesterol and phospholipid in liver were elevated by ADR-treated. Dietary coenzyme $Q_{10}$ reduced the increased hepatic cholesterol content in ADR-treated rat.