Antitumor and Immunomodulating Effects of Seaweeds toward Sarcoma-180cell

파래와 곤피에서 추출한 당단백질의 Sarcoma-180 cell에 대한 항암효과 및 면역활성

  • Lee, Young-Suk (Institute of Health and Environment, Pusan) ;
  • Kim, Dong-Seuk (Dept. of Food Science and Technology, Kyungsung University) ;
  • Ryu, Beung-Ho (Dept. of Food Science and Technology, Kyungsung University) ;
  • Lee, Sung-Hoo (Dept. of Food and Nutrition, Kyungnam Junior College)
  • 이영숙 (부산시 보건환경연구원) ;
  • 김동석 (경성대학교 공과대학 식품공학과) ;
  • 류병호 (경성대학교 공과대학 식품공학과) ;
  • 이성호 (경남전문대학 식품영양과)
  • Published : 1992.10.01

Abstract

This study was investigated on the antitumor effects of protein-polysaccharide fraction(PPF) extracted from seaweeds such as sea-lettuce and gonpi toward sarcoma-180 cells. In the PPF extracted from these seaweeds, the polysaccharide contents of sea-lettrce and gonpi were 52.20% and 48.16%, respectively. The highest levels of constituents monosaccharides found in seaweeds was fructose. The major amino acids were aspartic acid, glutamic acid, glycine and cystein. The solid tumor growth inhibition showed the highest level of 64.55% when 50mg/kg sea-lettuce was administerated. The life prolongation effect was 18.31% at 50mg/kg of gonpi. In the effects of immunologic activity, when 50mg/kg sea-lettuce was administrated, the number of circulating leucocyte showed the highest level (65.11%). The number of total peritoneal exudate cells of the sea-lettuce administerated group was increased significantly in comparison with the control group. The hematological analysis of the experimental group was similar with that of the control group.