Serum Cholesterol and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

혈청 콜레스테롤과 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

  • Choi, Yong-Soon (Dept. of Applied Biology and Technology, Kangweon National) ;
  • Lee, Sang-Young (Dept. of Food Science and Technology, Kanweon National University)
  • 최용순 (강원대학교 생물응용공학과) ;
  • 이상영 (강원대학교 식품공학과)
  • Published : 1992.10.01

Abstract

Cholesterol have many essential functions as a component of cellular and subcellular membranes, metabolic precursor of bile acids and steroid hormones, and obligatory part of the metabolic systems involved in DNA synthesis and cell division. These essential funtions demand a continuous and appropriate supply of cholesterol to the tissues. Body cholesterol pool is maintained by the balance of acquirement from diets, de novo synthesis, and excretion either as bile acids or neutral steroids. In these metabolic process, cholesterol biosynthesis is controlled by the change in the activity of 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase. Under most physiological or nutritional situations, the activity of this enzyme is adroitly regulated to maintain tissue cholesterol balance. Excess cholesterol accumulation in the cells induces the decrease in the number of LDL-receptor, followed by the increase in the level of serum LDL-cholesterol. Increase in the level of serum cholesterol appears to be an important determinant for the incidence of the coronary heart disease. Dietary intervention may be helpful in alleviating an increase in the level of serum cholesterol or body cholesterol pool.