Cerebral lesions of encephalitozoonosis in the rabbits died of rabbit hemorrhagic disease

토끼 출혈병(出血病)으로 죽은 토끼의 대뇌(大腦)에서 보인 encephalitozoonosis의 병변(病變)

  • Park, Jae-hak (Faculty of Comparative Pathology, Department of Veterinary Medicine, Hokkaido University) ;
  • Lee, Yong-soon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Itakura, C. (Faculty of Comparative Pathology, Department of Veterinary Medicine, Hokkaido University)
  • 박재학 (북해도대학 수의학부 비교병리학) ;
  • 이영순 (서울대학교 수의과대학 공중보건학) ;
  • 판창지민 (북해도대학 수의학부 비교병리학)
  • Received : 1992.03.10
  • Published : 1992.04.30


Out of twenty rabbits which died of rabbit hemorrhagic disease spontaneously occurring in Korea, five animals had a concurrent infection with Encephalitozoon cuniculi in the cerebrum. The lesions were composed of granulomas, leptomeningitis and perivascular cuffing with mononuclear cells. The granulomas consisted of a central necrotic focus surrounded by an infiltration with plasma cells, lymphocytes and macrophages. Gliosis was associated with the granulomas. Gram-positive organisms were detected in the cerebrum from two rabbits. They were oval to rod-shaped with blunt round ends. The distribution of the pathogens was investigated by the direct avidin-biotin peroxidase complex method. They were present in pseudocysts and macrophages. Pseudocysts were found in the granulomas as well as the neuropil without cellular reactions. Some organisms were present within reticulo-endothelial cells of blood capillaries and macrophages in the subarachnoid spaces. These organisms had ultrastructural characteristics consistent with Encephalitozoon cuniculi.