Spontaneous lingual papillomas in fischer 344 rats

Fischer 344 랫드의 혀 유두종(Lingual papilloma) 자연발생 예

  • Kang, Boo-hyun (Taxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Lim, Chang-hyeong (College of Veterinary Medicine, Seoul National University)
  • 강부현 (한국화학연구소 안전성연구센터) ;
  • 임창형 (서울대학교 수의과대학)
  • Received : 1992.07.20
  • Published : 1992.12.30


Two cases of lingual masses were observed among 500 Fischer 344 (F344) rats which were used as control and treated animals in a 2 year carcinogenicity study in Toxicology Research Center, Korea Research Institute of Chemical Technology. The masses grossly appeared as tan, pedunculated, fungiform on the dorsal aspect of the base of the tongues. They were approximately $1.5{\times}1.2{\times}0.3cm$ in size. The microscopic features consisted of acanthosis, hyperkeratosis, papillary projection with connective tissue cores and multifocal chronic active inflammation with hair shafts. The results observed support the epigenetic mechanism of tumorigenesis which is caused by Physical stimuli of foreign bodies. Both of the masses were diagnosed as papillomas with the incidence rate of 0.4%(1/250) in each sex on the basis of the gross and microscopic features.