Effect of Old Antler Extracts on the Galactosamine-induced Hepatotoxicity in Rats

녹각이 Galactosamine에 의해 유도된 간장해에 미치는 영향

  • 박은미 (영남대학교 식품영양학과) ;
  • 조수열 (영남대학교 식품영양학과) ;
  • 김명주 (영남대학교 식품영양학과)
  • Published : 1993.10.01

Abstract

This study was conducted to investigate the biochemical efforts of old antler extracts on the enzyme activities in serum of galactosamine (GaIN)-induced rats. Male rats of Sprague-Dawley strain weighing the average of 110$\pm$10g were divided into four groups and each group was fed either AIN-76 diet or modified AIN-76 diet with old antler extracts (water extract, neutral extract, ether extract) for four weeks. CaIN (400mg/ kg of body weight) was injected to CaIN treatment groups intraperitoneally on the same day every week. CaIN treatment decreased growth performance of rats. But dietary supplementation of old antler extracts prevented this decrement. Serum aminotransferase activities were increased by CaIN treatment, but this increment was reduced by feeding the old antler extracts, and the effect of water extract was the most prominent of the old antler extracts. Activities of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in serum of CaIN treatment groups were higher than those of control groups and were decreased by old antler extracts supplementation.