Substitution Reactions of Cyanopyridines with Organometallics

유기금속화합물에 의한 Cyanopyridines의 치환반응에 관한 연구

  • Kim, Jung-Gyun (Department of Chemistry, Pusan National University) ;
  • Yu, Dong-Sik (Department of Chemistry, Pusan National University) ;
  • Moon, Sung-Hwan (Department of Chemistry, Pusan National University) ;
  • Park, Jin-Il (Department of Chemistry, Pusan National University) ;
  • Park, Won-Woo (Department of Chemistry, Pusan National University)
  • 김정균 (부산대학교 자연과학대학 화학과) ;
  • 유동식 (부산대학교 자연과학대학 화학과) ;
  • 문성환 (부산대학교 자연과학대학 화학과) ;
  • 박진일 (부산대학교 자연과학대학 화학과) ;
  • 박원우 (부산대학교 자연과학대학 화학과)
  • Published : 1993.09.20

Abstract

3-Cyanopyridine, when treated with organolithium or Grignard reagents, gives addition to the 6-position and provides a series of 2-substituted 5-cyanopyridines (6-substituted 3-cyanopyridines). Alternatively, 2-and 4-cyanopyridine react with $CH_3Li$ or $CH_3Mgl$ and provide 2-acetylpyridine and 4-acetylpyridine, respectively.

Keywords

References

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