Effects of Dietary Irons Supplementation on ${\delta}-Aminolevulinic$ Acid Dehydratase Activity and Detoxification of the Pb-administered Rats

철보충이 납중독된 흰쥐의 ${\delta}-Aminolevulinic$ Acid Dehydratase 활성과 해독에 미치는 영향

  • 이정숙 (고신대학교 식품영양학과) ;
  • 조수열 (영남대학교 식품영양학과) ;
  • 김영로 (영남대학교 환경학과)
  • Published : 1994.02.01

Abstract

This study was designed to investigate the effects of dietary iron supplementationon ${\delta}-aminolevulinic$ acid dehydratase (DALAD) activity and liver damage of the lead(Pb)-administered rats. The iron (Fe) supplement levels were 100 ppm(Fe100) and 500ppm(Fe500) and the Pb-exposed rats were given 2, 000ppm-Pb in drinking water, while control rats were given neigher iron nor lead. Hematocrit was lower in the Pb, Fe100 -Pb, Fe500-Pb group than in the control, but was not affected by the Pb adminstration when the rats fed the Fe supplementation diet. DALAD activity were reduced by Pb added but, were higher in the Fe500-Pb group than in the Fe100 -Pb group. No significant difference was found in serum Pb content due to Pb administration and Fe supplementation. The liver Pb contentwas higher in the Fe supplementation group than in the Pb-group. Level of serum FE was lower in the Pb added groups than in the control group. Liver Fe contents were increased with Pb administration and higher in the Fe supplement groups than in the Pb-group. Levels of serum and liver copper was decreased with the Fe supplementation. Aminotransferase activity of serum and liver were increased in the Pb group.

References

  1. Medicine v.4 Lead poisoning Aub,J.C.;Fairhall,L.T.;Minot,A.S.;Reznikoff,P.
  2. Brit. J. Ind. Med. v.32 The effects of metal ions of δ-aminolevulinic acid dehydratase Thompson,J.J.;Beasley,W.H.
  3. Toxicol. Appl. Pharmacol. v.41 Influence of dietary factors of blood tissue lead Augusta,A.M.;Lornald,M.;Uthman,E.
  4. J. Pharm. Sci. Korea v.19 납중독에 있어서 δ-aminolevlinic acid dehydratase의 효과에 관한 연구 윤혜정
  5. J. Lab. Clin. Med. v.79 The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat Six,K.M.;Goyer,R.A.
  6. Nutrition and environmental health Edward,J.C.
  7. J. Nutr. v.106 Influence of dietary selenium on lead toxicity in the rat Cerklewski,F.N.;Forbes,R.M.
  8. J. Med. v.284 δ-aminolevulinic acid dehydratase activity in circulating blood cells Weissberg,J.B.;Lipschutz,F.;Oski,F.
  9. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitman,S.;Frankel,S.
  10. J.A.O.A.C. v.51 Mineral in feeds by atomic absorption spectrophotometry Heckman,M.
  11. Principles procedures of statistics Steel,R.G.;Torrie,J.H.
  12. 한국영양학회지 v.19 no.4 단백질 급원과 수준을 달리한 식이가 흰쥐의 납 축적에 미치는 영향 김옥경;서정숙;이명환
  13. Toxicol. Appl. Pharmacol. v.41 Influence of dietary factors on blood and tissue lead concentrations and lead toxicity Mylroie,A.A.;Moore,L.;Uthman,E.
  14. Pediat. Res. v.11 Experimental lead poisoning and intestinal transport of glucose, amino acid and sodium Wapnir,R.A.;Exeni,R.A.;Mcvicar,M.;Lifsheitz,F.
  15. Environ. Res. v.12 The effects of dietary lead content and food restriction on lead retention in rats Quarterman,J.;Morrison,J.N.;Humphries,W.R.
  16. J. Nutr. v.109 Effect of dietary supplementaion of iron and ascorbic acid on lead toxicity in rats Suzuki,T.;Yoshida,A.
  17. 한국영양학회지 v.18 no.4 유년기 백서의 단백질 부족이 성장후 납중독에 미치는 영향 김양선;유정열
  18. J. Nutr. v.107 Anemia of lead intoxication : A role for copper Klauder,D.S.;Petering,H.G.
  19. Nutr. Rev. v.34 no.11 Recommendations for the prevention of lead poisoning in children Chisolm,J.J.
  20. Lead effects on the heme biosynthetic pathway Moore,M.R.;Goldberg,A.;Yeung-Laiwah,A.A.
  21. Scientic American v.224 Lead poisoning Chisolm,J.J.
  22. 중대논문집 납중독에 있어서 고려 인삼근 수침액의 해독효과에 관한 연구 ( I ) 김윤영
  23. Arch. Biochem. Biophys. v.144 Biochemical effects of mercury, cadmium and lead Vallee,B.L.;Ulmer,D.D.
  24. Gastroenterology v.74 Factors affecting the absorption and excretion of lead in the rat Conrad,M.E.;Barton,J.C.
  25. J. Biol. Chem. v.239 The biochemistry of animals cells, the effect of corticosteroids of leakage of enzyme from dispersed rat liver cells Takeda,Y.;Ichihara,A.;Tanioka,H.;Inove,H.
  26. Behavioral Sciences and Health Care v.1 Blood lead of iron deficient children-increase following iron supplementation Carol,R.;Matilda,S.M.
  27. Nephron v.2 The anemia of lead poisoning Galle,P.;Morel-Marager,L.
  28. J. Nutr. v.107 Influence of dietary copper on lead toxicity in the young male rat Cerklewski,F.L.;Forbes,R.M.