백서에서 Paraquat가 장기 Glutathione 농도에 미치는 영향

  • Published : 19940100

Abstract

The effects of paraquat administration on glutathione was studied in rats. The contents of glutathione in the liver, kidney and lung were significantly decreased but the alteration was not significant in blood by paraquat administration. The decrease occured without concomitant increases in oxidized glutathione (GSSG) or in the GSH/GSSG ratio. The activities of γ-glutamylcysteine synthetase in liver and kidney were decreased by paraquat administration. And γ-glutamyl transpeptidase activities were significantly decreased in kidney and lung of paraquat treated-rats. These results suggest that the decreased synthesis of glutathione by paraquat were an important mechanism of the decreased level of glutathione in liver and kidney, and decreased glutathione transport was a factor on the changes of glutathione contents in lung.

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References

  1. J. Biol. Chem. v.263 Krall, J.;Bagley, A. C.;Mullenbach, G. T.;Hallewell, R. A.;Lynch, R. E.
  2. Methods in Enzymol v.113 Tate, S. S.;Meister, A.
  3. J. Biol. Chem. v.193 Lowry, C. H.;Rsenbrough, N. J.;Farr, A. L.;Randall, R. J.
  4. Br. J. Radiol. v.54 Deschavanne, P. J.;Malaise, E. P.;Revesz, L.
  5. Methods in Enzymolgy v.186 Halliwell, B.;Gutte, J. M. C.;Fleischer, S.(ed.);Packer, L.(ed.)
  6. Arch. Biochem. Biophy. v.196 Hassan, H. M.;Fridovich, I.
  7. Toxical Appl Pharmacol. v.153 Kornbrust, D. J.;Mavis, R. D.
  8. Arch Biochem Biophy. v.235 Sutton, H. C.;Winterbourn, C. C.
  9. Biochim. Biophys. Acta v.716 Keeling, P. L.;Smith, L. L.;Aldridge, W. N.
  10. Mol. Cell. Biochem. v.39 Tate, S. S.;Meister, A.
  11. Methods Enzymol. v.77 Meister, A.;Tate, S. S.;Griffith, O. W.
  12. J. Biol. Chem. v.254 Griffith, O. W.;Meister, A.
  13. FEBS Lett. v.27 Sies, H.;Gerstenecker, C.;Summer, K. H.;Menzel, H.;Floh, L.
  14. Int. J. Radiat. Biol. v.37 Edgren, M.;Lasson, A.;Nilsson, K.;Revesz, L.;Scott, O. C.
  15. Anal. Biochem. v.27 Tietze, F.
  16. Biochem. Biophys. Acta v.883 Naoko, W.;Yasuko, S.;Nobuhiro, M.;Yasushi, S.;Sho, Y.
  17. Ann. Revi. Biochem. v.52 Meister, A.;Anderson, M. E.
  18. J. Biol. Chem. v.264 Fridovich, I.
  19. Methods Enzymol v.113 Meister, A.