Studies on the Synthesis of New Medicinal Agent (Ⅲ) : Studies on the Synthesis and Antibacterial Activites of New Cephalosporin Derivatives

새로운 의약품의 합성에 관한 연구 (Ⅲ) : 새로운 세파로스포린 항생물질의 합성과 그의 생물활성에 관한 연구

  • 최원식 (순천향대학교 유전공학과) ;
  • 최소영 (순천향대학교 유전공학과)
  • Published : 19940800

Abstract

New cephalosporin antibiotics,7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl)acetamido]-3-[(substituted pyrimidin-2-yl)thiomethyl]-3-cephem-4-carboxylic acid derivatives(2a∼2d) were synthesized. These new cephalosporin derivatives were prepared by the introduction of pyridinylthiomethyl moiety in 3-position and thiazine group in 7-position of 7-ACA. Antibacterial activities of these compounds were examined and the relationship between structure and activities were studied. As the result, these compounds showed low antibacterial activities compared to cefotaxim used as control.

Keywords

References

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