Effect of berberine on intestinal contractility

장 평활근의 수축성에 대한 berberine의 효과

  • Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
  • 신동호 (전남대학교 수의과대학)
  • Received : 1994.01.25
  • Published : 1994.01.31

Abstract

Berberine $(10^{-7}-10^5M)$ increased the contractility dose-dependently in isolated rabbit ileal and jejunal segments. Atropine and hemicholinium abolished this response but not mecamylamine. Berberine$(10^{-8}-10^5M)$ enhanced the transmurally-stimulated(80 V, 0.5 ms, 0.05 Hz) twitch response in the isolated guinea-pig ileal segments. Atropine and hemicholinium also abolished this response but not mecamylamine. Effect of KCI, carbachol and histamine were not affected by pretreatment with berberine$(10^{-5}M)$. The results of our study suggest that berberine increases the intestinal contractility by increasing a small amount of acetylcholine release from the postganglionic parasympathetic nerve terminal but not by a direct activation of muscarinic receptors.

Acknowledgement

Supported by : 전남대학교