A Study on efficacy and safety of antibacterial(pefloxacin methanesulfonate) to cultured fish, Cyprinus caprio and Paralichthys olivaceus

양식어류(이스라엘 잉어, 넙치)에 대한 항균물질 pefloxacin의 효능 및 안전성에 관한 연구

  • Heo, Gang-joon (Laboratory of Aquatic Animal Disease, Department of Veterinary Medicine, College of Veterinary Medicine Chungbuk National University) ;
  • Kim, Jeong-ho (Laboratory of Aquatic Animal Disease, Department of Veterinary Medicine, College of Veterinary Medicine Chungbuk National University)
  • 허강준 (충북대학교 수의과대학 수의학과 어류질병학연구실) ;
  • 김정호 (충북대학교 수의과대학 수의학과 어류질병학연구실)
  • Received : 1993.12.16
  • Published : 1994.01.31

Abstract

A study on quinolone antibacterial (pefloxacin methanesulfonate) was performed to use for the drug of fisheries. Petloxacin was proved excellent in antibacterial activity and resistance against fish pathogens when compared with the existing antibacterials. And any side effect was not observed during the period of indicated use. An outline of MIC(Minimal Inhibitory Concentration) was $1.6{\sim}6.4{\mu}g/ml$, $TLm_{48h}$ value were 380~420 ppm in Israeli carp(Cyprinus caprio) and 2100~2300 ppm in flounder(Paralichthys olivaceus). The residual time of fish body was less than 15 days. So we can treat some bacterial disease of fish by the dosage of 100 g/day/ton of fish body weight for 3 days and pefloxacin is thought to be used effectively and widely against most bacterial fish pathogens.