Observations of a endometrial stromal sarcoma in the rat uterus wall

Rat의 자궁벽에 발생된 stromal sarcoma의 관찰

  • Kwak, Soo-dong (College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Chong-sup (College of Veterinary Medicine, Gyeongsang National University)
  • 곽수동 (경상대학교 수의과대학) ;
  • 김종섭 (경상대학교 수의과대학)
  • Received : 1994.07.09
  • Published : 1994.07.30


The present observation was focussed mainly on the histopathological and immunohistochemical finding of the tumor developing from the outside of rat uterus wall. In gross finding, this tumor were a oval form mass and 0.75cm and 1cm in greatest demension. The sectioned surface showed uniform, solid, gray-white. In histopathological finding, the tumor showed the form of lymphoid nodule-like structure and was composed of the cells with karryorrhexis, karyolysis and necrosis in the central zone, mature cells in the paracentral zone, and concentric layers of compressed, flattened and atrophied smooth muscle fibers by the proliferating of the cells closely resembling endometrial stromal ells in the peripheral zone and a few smaller nodule-like structure in certain areas of the peripheral zone. In immunohistochemical observations, the proliferating cells presents only among the concentric layers of the smooth muscle fibers in the peripheral zone. Labeling index of proliferating cells in the peripheral zone was $4.34{\pm}1.28%$. These tumor cells did not metastasized in another orgns and labeling index was low, So it was concluded that this tumor was benign stomal sarcoma.