Effects of serum on lymphokines producing capabilities of CD8+ T cells

Serum이 CD8+ T cell의 lymphokine 생산양상의 변화에 미치는 영향

  • Ryu, Si-yun (College of Veterinary Medicine, Chungnam National University) ;
  • Yoon, Won-kee (College of Veterinary Medicine, Chungnam National University) ;
  • Cho, Sung-whan (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Moo-kang (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Tae-hwan (Laboratory of Radiation Medicine, Korea Cancer Center Hospital)
  • 류시윤 (충남대학교 수의과대학) ;
  • 윤원기 (충남대학교 수의과대학) ;
  • 조성환 (충남대학교 수의과대학) ;
  • 김무강 (충남대학교 수의과대학) ;
  • 김태환 (한국원자력병원 방사선의학연구실)
  • Received : 1994.07.22
  • Published : 1994.07.30

Abstract

The responsiveness of $CD8^+$ T-cell subpopulation according to serum-containing and serum-free conditions were investigated. Cells are freshly isolated from spleen of mature adult BALB/C mice between 13-20 weeks of age. $CD8^+$ T cells in serum-free conditions produce small amounts of IL-2, while significant amounts of IFNr following activation when compared the results of serum-containing conditions. These data indicate that serum-derived factors may play an important role in the alternations of $CD8^+$ T cell responsiveness.