Fetal growth retardation induced by maternal exposure to phenol in the rat

임신 랫트의 페놀 노출에 따른 태자의 발육 지연효과

  • Chung, Moon-koo (Korea Research Institute of Chemical Technology, Toxicology Research Center)
  • 정문구 (한국화학연구소 안전성연구부)
  • Received : 1994.05.12
  • Published : 1994.07.30


This study was carried out to investigate the potential of phenol to induce embryotoxicity in the Sprague-Dawley rat. Seventy mated rats were distributed among three treated troups, a vehicle control group and a negative control group. Phenol was at dose levels of 20, 60 and 180mg/kg/day adminsistered by gavage to pregnant rats three times per day from days 7 to 12 of gestation. All dams were subjected to the caesarean section on day 20 of gestation. At 120mg/kg, dams exhibited decreased locomotivity. In addition, both weight reduction and retarded ossification of fetuses were observed. There were no signs of maternal toxicity or embryotoxicity at 20 and 60mg/kg. The results show that phenol induces fetal growth retardation at maternally subtoxic dose in rats.