Acute and subacute toxicity of fumonisin B1 to fingerlings of common carp, Cyprinus carpio

잉어치어(稚魚)에 대한 곰팡이독(fumonisin B1)의 급성(急性) 및 아급성독성(亞急性毒性)에 관한 연구

  • Heo, Gang-joon (College of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Jin-hee (College of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Yong-soon (College of Veterinary Medicine, Seoul National University) ;
  • Lim, Yoon-kyu (Department of Veterinary Medicine, Cheju National University)
  • 허강준 (충북대학교 수의과대학 수의학과 어류질병학연구실) ;
  • 이진희 (충북대학교 수의과대학 수의학과 어류질병학연구실) ;
  • 이영순 (서울대학교 수의과대학) ;
  • 임윤규 (제주대학교 농과대학 수의학과)
  • Received : 1995.06.05
  • Published : 1995.10.30

Abstract

The acute and subacute toxicity of fumomsin $B_1$ was evaluted in fingerlings of common carp, Cyprinus carpio. Dipping of fish for acute toxicity was performed for a period of 48 hours, and the $TLm_{48h}$ value(median tolerance limit) was more than 1000 ppm in common carp. Severe damages were observed in various organs and among them, clubbing of gill lamella, lytic degeneration and vacuolation of liver cells, and epithelial edema of renal tubules were relatively prominent. The most significant changes were hyperbasophilic foci of liver cells in subacute toxicity test and these can imply the possibility of hepatocarcinogenecity of fumonisin $B_1$.