Activity Change of Ornithine Decarboxylase(ODC) after Hepatectomy

  • Chang Sung (Dept. of Food Science and Technology, Chungnam National University) ;
  • Jou, Kab-Yeo (Dept. of Food Technology, Joongkyoung Technical Junicor College) ;
  • Ha, Duk-Mo (Dept. of Food Technology, Dongguk University)
  • Published : 1995.06.01

Abstract

Ornithine decarboxylase(ODC) catalyzes the first and key step in the polyamine biosynthetic pathway. Ornithine decarboxylase is known to the enzyme that increase substantially its activity in regenerating liver. We found that activity and mRNA level for ODC increase significantly after partial hepatectomy in the rat. After laparotomy, there was significant decrease in activity ; however, mRNA content was unaltered in contrast to previous reports of no change in ornithine decarboxylase and thymidine kinase after sham hepatectomy. This may be mediated by the decrease in food intake after hepatectomy. Therefore it is necessary to examine the effect of food intake after hepatectomy on the ODC activity and mRNA level in the future.

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