GC-MS Analysis of Diterpene Quinone Constituents of Salviae Miltiorrhizae Radix and Biological Activity

  • Park, Hee-Juhn (Dept. of Botanical Resources, Sangi University) ;
  • Lee, Seung-Bae (Dept. of Dairy Food Science, Sangji University) ;
  • Lee, Eun (Dept. of Dairy Food Science, Sangji University) ;
  • Cha, Bae-Chun (Dept. of Animal Nutritional Resources, Sangji University) ;
  • Park, Moo-Young (Dept. of Food Science & Nutrition, Sangji University) ;
  • Lee, Sung-Mok (Central Research Institute, Il-Yang Pharm. Co., Yongin) ;
  • Chung, Won -Tae (Central Research Institute, Il-Yang Pharm. Co., Yongin)
  • Published : 1995.06.01

Abstract

The ether extract of Salviae miltiorrhizae Radix(SMR) was fractioned to give five subfractions, so that two subfractions of them were recrystallized to yield each pure diterpene quinone pigment. On the basis of spectral evidence, these two compounds were identified as tanshinone II and crytotanshinone. Cryptotanshinone exhibited both of a potent platelet anti-aggregating activity in vitro and a potent antimicrobial activity. GC-MS analysis of the other extract showed that tanshinone II was contained in the largest proportion of all the diterpene quinones. In addition, GC-MS analysis gave other valuable analytical informations.

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