Antiviral Effect of Lithium-Ascorbate Derivatives

아스코르빈산-리듐 유도체의 바이러스에 대한 불활성화 작용

  • Kil-Jin Kang (Dept. of Food Science and Technology, and Institute of Agriculture Science & Technology, Chonnam National University) ;
  • Akira Murata (Dept. of Applied Biological Science, Saga University)
  • Published : 1995.06.01

Abstract

The effect of lithium-ascorbate derivatives on viruses was investigated using a wide variety of bacterial viruses(phage). Lithium-ascorbate derivatives exerted an inactivating effect on all phages examined. Lithium-ascorbate derivatives have antiviral effects. The antiviral effect of lithium 2-o-octadecyl ascorbate was stronger than that of lithium ascorbate. Even at 10∼20 times lower concentration, the lithium 2-o-octadecyl ascorbate showed very much similar phage inactivating effect to that of ascorbate and lithium ascorbate.

References

  1. Congr. Int. Assoc. Microbioal. Soc. v.3 Virucidal activity of vitamin C, in Proc. 1st. Intersect. Murata,A.;Hasegawa,T.(ed.)
  2. Virus-inactivating effect of L-ascorbic acid v.20 Tanpkkushitsh Kakusan Koso(Protein Nucleic acid Enzyme.) Murata,A.
  3. J. Nutr. Sci. Vitaminol. v.21 Mechanisom of inactivation of phage δ A by ascorbic acid. Murata,A.;Oyadomari,R.;Ohashi,T.;Kitagawa,K.
  4. J. Nutr. Sci. Vitaminol. v.22 Mechanism of inactivation of pharge MS2 by asorbic acid. Murata,A.;Uike,M.
  5. Bitamin(vitamins) v.57 Inactivating effect of ascorbic acid on double-stranded RNA phage. Murata,A.;Suenaga,H.;Inoue,M.;Tanaka,Y.;ato,F
  6. Agric. Biol. Chem. v.37 Mechanism of in activation of pharge by ascorbic acid. Murata,A.;Kitagawa,K.
  7. Agic. Biol. Chem. v.50 Hydroxyl radical as the reactive species in the inactivation of phages by ascorbic acid. Murata,A.;Sunenga,H.;Hideshima,S.;Tanaka,Y.;Kato,F.
  8. Biosci. Biotech. Biochem. v.56 Phage-inactivating effect of iron(Ⅱ)-ascorbate complex. Lho,I.H.;Morita,K.;Myyake,H.;Sakamoto,K.;Kanda,K.;Kato,F.;Murata,A.
  9. Agric. Biol. Chem. v.35 Temperature-sensitive growth of wild-type phage Ⅱ of Lactoacillus casei. Murata,A.
  10. J. Virol. v.11 Phage Φ6 ;a lipid-containing virus of Pseudomonas phaseolicola. Vidaver,A.K.;Koshi,P.K.;Van Etten,J.L.
  11. Bacteriophages. Adams,M.H.
  12. Factors influencing plaque formation by phages of Lactobacillus acidophilus. v.43 Murata,A.;Soeda,E.;Saruno,R.