Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography

항갑상선 의약물 중 2-mercapto-1-methyl-imidazole의 펄스차이 폴라로그래피에 의한 분석

  • Received : 1994.11.25
  • Published : 1995.03.25


The determination method of 2-mercapto-1-methyl-imidazole(MMI) in $5.0{\times}10^{-2}M$ lithium perchlorate solution has been investigated by the differential pulse polarography. The optimum conditions for the determination of MMI were as fellows; -0.9 volt(vs. Ag/AgCl) initial potential, 80mV pulse height, 2mV/sec scan rate, and medium mercury drop size. The calibration curve showed a good linearlity in the range of $1.0{\times}10^{-7}M$ to $8.0{\times}10^{-5}M$ and the detection limit was $2.2{\times}10^{-9}M$. This method was applicable to the determination of MMI in thyroid drugs without interference from the additives.


2-mercapto-1-methyl-imidazole;differential pulse polarography


Supported by : 한국과학재단