Ion-Selective Electrodes for the Determination of Alverine

Alverine의 정량을 위한 Ion-Selective Electrodes

  • Lee, Eun-Yup (Department of Pharmacy, Kyungsung University) ;
  • Kim, Ki-Myo (Department of Pharmacy, Kyungsung University) ;
  • Kim, Sung-Jin (Department of Pharmacy, Kyungsung University) ;
  • Hur, Moon-Hye (Department of Pharmacy, Kyungsung University) ;
  • Ahn, Moon-Kyu (Department of Pharmacy, Kyungsung University)
  • 이은엽 (경성대학교 약학대학 약학과) ;
  • 김기묘 (경성대학교 약학대학 약학과) ;
  • 김성진 (경성대학교 약학대학 약학과) ;
  • 허문희 (경성대학교 약학대학 약학과) ;
  • 안문규 (경성대학교 약학대학 약학과)
  • Received : 1995.01.13
  • Published : 1995.03.25

Abstract

Ion-selective poly(vinyl chloride) membrane electrodes for the determination of the anticholinergic drug alverine in pure substances is described. Ion-pair complex of alverine with anionic counter ion acid red 97 is investigated as electroactive compound for the electrode membrane. On the optimal composition of membrane, its slope was 55.35mV/decade, relative standard deviation was 0.61 and lower limit of linear range was $1.0{\times}10^{-5}M$. The observed potentiometric selectivity coefficient was -2.625 toward methylephedrine and -2.216 toward histidine. We can got the stable potential at pH 7.0~4.0. Response time was 20~30 seconds for solutions${\leq}10^{-4}M$, about 10 seconds for solutions ${\geq}10^{-4}M$ of these compounds.

Keywords

Ion-selective electrode;anionic counter ion;acid red 97;alverine