Anticoccidial effects of artemisinin on the Eimeria tenella

Artemisinin의 Eimeria tenella에 대한 항콕시듐 효과

  • Oh, Hwa-gyun (Dept. of Parasitology, College of Vet. Medicine, Seoul National University) ;
  • Youn, Hee-jeong (Dept. of Parasitology, College of Vet. Medicine, Seoul National University) ;
  • Noh, Jae-wuk (Bayer Veterinary Medical Research Institue, Bayer Vetchem(Korea)) ;
  • Jang, Du-hwan (Dept. of Parasitology, College of Vet. Medicine, Seoul National University) ;
  • Kang, Yung-bai (Veterinary Research Institute in RDA)
  • 오화균 (서울대학교 수의과대학 기생충학교실) ;
  • 윤희정 (서울대학교 수의과대학 기생충학교실) ;
  • 노재욱 (한국바이엘화학(주) 동물의약연구소) ;
  • 장두환 (서울대학교 수의과대학 기생충학교실) ;
  • 강영배 (가축위생연구소)
  • Received : 1994.10.18
  • Published : 1995.01.31

Abstract

Artemisinin, a sesquiterpene lactone, is isolated from the leafy portion of the Artemisia annua and has been known to be effective against Plasmodium species. Since the genera of Plasmodium and Eimeria(E) tenella are included the same order, Eucoccidiidae, it is presumed that artemisinin may also be effective against E tenella. In order to study the anticoccididal effects of artemisinin, the chickens inoculated with E tenella were treated with artemisinin at different concentrations as feed additive and the results were compared to those of non-medicated, infected control(NIC) and non-medicated, non-infected control(NNC) group. Artemisinin demonstrated anticoccidial effects by showing, compared to NIC group, improved results in all parameters, such as bloody diarrhea, lesion scores, the numbers of excreted oocystis in feces, body weight gain and feed conversion rate. Anticoccidial index(ACI) of artemisinin treated group (5ppm~50ppm) was higher than that of NIC group. Improvements were greatest in the group treated with artemisinin 50ppm with an ACI of 147.6. These results indicate that artemisinin has anticoccidial effects on the Eimeria tenella.