Cholinergic contraction to the perivascular nerve stimulation on the isolated coronary artery of pig

돼지 적출 심관상동맥에 있어서 perivascular nerve stimulation에 의한 cholinergic 수축 작용

  • Shim, Cheol-soo (Eastern Branch, Gyeongnam Animal Health Institute) ;
  • Park, Sang-eun (Central Branch, Gyeongnam Animal Health Institute) ;
  • Jeon, Seok-cheol (Cardiac Center, Masan Koryo General Hospital) ;
  • Han, Bang-keun (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Joo-heon (College of Veterinary Medicine, Gyeongsang National University)
  • 심철수 (경상남도 가축위생시험소 동부지소) ;
  • 박상은 (경상남도 가축위생소 중부지소) ;
  • 전석철 (마산고려병원 심장센터) ;
  • 한방근 (전남대학교 수의과대학) ;
  • 김주헌 (경상대학교 수의과대학)
  • Received : 1995.01.24
  • Published : 1995.04.30

Abstract

The effects of various autonomic blocking agents to perivascular nerve stimulation were investigated on isolated coronary artery of pig. 1. The magnitude of contractile response to perivascular nerve stimulation increased with increasing frequency(280Hz) of stimulation. 2. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were increased by pretreatment of the cholinestrase inhibitor, physostigmine. 3. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was antagonised by the muscarinic antagonist, atropine. 4. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was blocked by the neural blocker, tetrodotoxin. 5. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were not significantly affected by the ${\alpha}$-adrenergic antagonist, phentolamine or ${\beta}$-adrenergic antagonist, propranolol. 6. The contractile response by the acetylcholine was increased by the pretreatment of cholinestrase inhibitor, physostigmine. This findings suggest that the powerful excitatory action by the perivascular nerve stimulation may be linked to muscarinic receptor by cholinergic nerve excitation in coronary artery of pig.