- Volume 35 Issue 2
GI transition and disintegration test of enteric coated capsules using radiopaque material in rabbits
토끼에서 조영제를 이용한 장용성 capsule의 GI transition과 disintegration에 관한 검사
- Kim, Myung-cheol (College of Veterinary Medicine, Chungnam National University) ;
- Kim, Nam-joong (Lucky Biotech R&D Center)
- Received : 1995.02.15
- Published : 1995.04.30
This study was carried to investigate the usefulness of the radiopaque material as the GI transition and disintegration test of enteric coated capsules radiologically. The obtained results were as follows; 1. The GI transition times that the enteric coated capsules pass through the pylorus were that the time of the first capsule was 210 minutes and the time of the last capsules was more than 300 minutes. Therefore, the GI transition times largely differ from each animal and each enteric coated capsule. 2. The disintegration times of enteric coated capsules were similar in vitro test and in vivo test. 3. The GI transition and disintegration test of enteric coated capsules using barium sulfate, radiopaque material for the gastrointestinal track, was useful to investigate the times that the capsules passed through the pylorus and disintegrated in intestinal track.