Antimutagenic Effects of Bifidobacteria

Bifidobacteria에 의한 항돌연변이 효과

  • Lee, Sae-Kyung (Department of Food Science and Nutrition, Hallym University) ;
  • Ji, Geun-Eog (Department of Food Science and Nutrition, Hallym University)
  • 이세경 (한림대학교 식품영양학과) ;
  • 지근억 (한림대학교 식품영양학과)
  • Published : 1996.08.30


The antimutagenic properties of twenty-one strains of Bifidobacterium were examined using Salmonella typhimurium TA98 in an in vitro assay system. The mutagens utilized for testing included Trp-P-1 (3-amino-1, 4-dimethyl-$^{5}H-pyrido$ (4, 3-b) indole), benzopyrene, IQ (2-amino -3-methylimidazo [4,5-f] quinoline), and NQO. The lyophilized cells of strain showed inhibitory effect of 64, 38, 29 and 20% in average against Trp-P-1, benzopyrene, NQO and IQ, respectively. There was no marked variation between each strain or growth stage in the degree of antimutagenicity against Trp-P-1, benzopyrene and IQ. Twelve hour grown cells showed higher antimutagenicity against NQO than 5-day grown cells. The results indicate that Bifidobacterium cells had a antimutagenic effect against several well-known mutagens to some degree.