Effects of Aluminum Compounds on Kidney Metabolism and Plasma Hormone of Rats

알루미늄 화합물이 흰쥐의 신장대사 및 혈장 Hormone에 미치는 영향

  • 한성희 (원광대학교 생명자원과학대학) ;
  • 김중만 (원광대학교 생명자원과학대학) ;
  • 백승화 (원광대학교 생명자원과학대학) ;
  • 이호섭 (원광대학교 한의학과) ;
  • 박성수 (원광대학교 생명자원과학대학)
  • Published : 1996.02.01

Abstract

The study was performed to investigate the effects of administration of aluminum compound in Kidney metabolism and plasma hormone of rats. Seventy frve male Sprague-Dawley strains rats were divided into five groups consisting of the control, 250ppm AlCl$_3$group, 500ppm AlCl$_3$ group, 250ppm $Al_2$(SO$_4$)$_3$group, 500ppm $Al_2$(SO$_4$)$_3$group and kept on the diet for 2 weeks. The body weight gain was increased by the administration of AlCl$_3$ but decreased by the administration of $Al_2$(SO$_4$)$_3$as compared to the control. The urinary excretion of sodium and creatinine were increased and free water clearance and urine volume were decreased significantly after AlCl$_3$adminstration group as compared to the control. The water balance, free water clearance, excretion of sodium and creatinine were increased and the excretion of chlorine was decreased after $Al_2$(SO$_4$)$_3$ administration as compared to the control. Plasma renin activity was increased and plasma aldosterone content was compared to the control. Plasma renin activity was increased and plasma aldosterone content was significantly decreased after adminstration of aluminum compounds as compared to the control.

References

  1. 식품공업 v.123 알루미늄 식품섭취의 문제점과 과량섭취 가능성 김중만;한성희
  2. American Academy of Pediatrics v.78 Aluminum toxicity in infants and children Harry, S. D.;Fredrick, H.;Norman,K.;Alvin, M. M.;John, W. R.
  3. Kidney. Int. v.23 Animal model of aluminum-induced osteomalacia : role of chronic renal failure Roberston, J. A.
  4. Am. J. Clin. Nutr. v.33 Metabolism and toxicity of aluminum in renal failure Alfrey, A. C.;Hegg, A.;Craswell, P.
  5. Fd. Chem. Toxic. v.21 The prophylactic reductin o aluminum intake Lione, A.
  6. New. Engl. J. Med. v.296 Gastrointestinal absorption of aluminum from aluminum-containing antacids Kaehny, W. D.;Hegg, A. P.;Alfrey, A. C.
  7. J. Lab. Clin. Med. v.90 Evidence for aluminum absorption from the gastrointestinal tract and bone deposition by aluminum carbonate ingestion with normal renal function Recker, R. R.;Blotcky, J. A.;Leffler, J. A.;Rack, E. P.
  8. Clin. Chem. v.25 Metabolic balance of aluminum studies in six men Gorsky, J. E.;Diedtza, A. A.;Spencer, H.;Osis, D.
  9. Am. J. Clin. Nutr. v.36 Effects of small doses of aluminum containing antacids on calcium and phosphorus metabloism Spencer, H.;Kramer, L;Norris, C.;Osis D.
  10. Arch. Pathol.3 v.8 The effects of aluminum on mamalian blood and tissues Seibert, B.;Wells, H.
  11. Amer. J. Clin. Nutrition. v.35 Aluminum loading during total parenteral nutrition Klein, G. L.;Alfrey, A. C.;Miller, N. L.;Sherrard, D. J.;Hazlet, T. K.;Pharm, D.;Ament, M. E.;Coburn, J. W.
  12. Annals of Interal Medicine v.104 Bilary excretion of aluminum in aluminum osteodystrophy with liver disease Williams, J. W.;Vera, S. R.;Peters, T. G.;Luther, R. W.;Bhattacharya, S.;Spears, H.;Graham, A.;Pitcock, J. A.;Crawford, A. J.
  13. J. Lab. Clin. Med. v.92 Aluminum kinetics during hemodialysis Kovalchik, M. T.;Kaehny, W. D.;Jackson, T.;Alfrey, A. C.
  14. New. Engl. J. Med. v.294 The dialysis encephalopathy syndrome, possible aluminum intoxication Alfrey, A. C.;Legendre, G. R.;Kaehny, W. D.
  15. Neurotoxicology v.Ⅰ Aluminum in human brain disease an overiew Crapper Mclachlam, D. R.;DeBoni, U.
  16. J. Clin. Pathol. v.32 Bone aluminum in hemo-dialysed patient and in rats injected with aluminum chloride : relationship to impaired bone mineralization Eills, H. A.;McCarthy, J. H.;Herrington J.
  17. Science v.217 Intraneuronal aluminum accumulation in amytrophic lateral sclerosis and parkinsonism-dementia of Guam Perl, D. P.;Gajdusek, D. C.;Garruto, R. M.;Yanagihara, R. T.;Gibbs, C. J.
  18. Series Neurology v.434 The basic processure anytrophic lateral sclerosis as reflected in Kil peninsula and guam excerpta medical international congress Yase, Y.
  19. Lancet v.1 Osteomalacia dialysis osteodystrophy : evidence for a water-bone aetiological agents, probably aluminum Ward, M. K.;Feest, T. G.;Eills, M. A.;Parkinson, I. S.;Kerr, D. N. S.
  20. Kidney Int. v.29 Dialysis encepahlopathy Alfrey, A. C.
  21. Lancet v.1 Brain-aluminum concentration in dialysis encephalopathy Mcdermott, J. R.;Smith, A. I.;Waed, M. K.;Fawcett, R. W. P.;Kerr, D. N. S.
  22. The kidney Brener, B. M.;Rector, F. C.
  23. J. Am. Med. Assoc. v.174 Hypotensive agents and pressor substances Laragh, J. H.;Angers, M.;Kelly, W. G.;Liberman, S.
  24. Am. J. Physiol. v.49 Studies on the nervous control of the kidney in relation to diuresis and urinary secretion Marshall, E. K. J.;Kolls, A. C.
  25. J. Clin. Invest. v.56 Effects of acute unilateral renal denervation in the rat Bello-Reuss, E.;Colindress, R. E.;Pastoriza-Munoz, E.;Muleller, R. A.;Gottschalk, C. W.
  26. Neurotoxicol v.1 Aluminum metabolism in uremia Alfrey, A. C.
  27. In quantitative clinical chemistry methods v.2 Philips, R. A.;J. P. Peter(Ed.);Vanslyke, D. D.(Ed.)
  28. J. Exp. Zool. v.242 Radio immunoassay and characterization of renin-angiotensin system in the freshwater turtle Cho, K. W.;Kim, S. H.;Koch, G. Y.
  29. Sci. v.144 Antibodies to bradykinin and angiotensin a use of carbodiimide in immunology Goodfriend, T. L.;Levine, L.;Fasman, G. D.
  30. Am. J. Physiol. v.236 Renin inasctivation during in vitro experimental Cho, K. W.;Malvin, R. L.
  31. Am. J. Med. v.55 Searching out low renin patients limitation of some commonly used methods Sealey, J. E.;Laragh, J. H.
  32. Jeon. Bug. Nat. Univ. Thesis Collection, (Natural Science) v.24 Measurement of plasma renin activity by radioimmunoassay in microscale in small laboratory animal Cho, K. W.;Kim, S. H.
  33. Kor. J. Physiol. v.16 Factors affecting the relationship between renal renin activity and plasma renin activity Cho, K. W.;Kim, S. H.
  34. Lancet v.11 Aluminum toxicity in rats Berlyne, N. C.;Yagil, R.;Ben Arj, J.;Weinberger, G.;Knopf, E.;Danovitch, G. M.
  35. 음용수의 수질관리 지침서 보건사회부
  36. Ann. Rev. Physiol. v.42 Potassium transport in the nephron Giebish, G.;Stanton, B.