Effect of Water Extract from Fugu xanthopterus on the Hyperuricemia in Alcohol-treated Rats

복어추출물이 Alcohol성 고요산혈증에 미치는 영향

  • 김석환 (동아대학교 식품영양학과) ;
  • 이경희 (동아대학교 식품영양학과) ;
  • 신두임 (동아대학교 식품영양학과) ;
  • 김동훈 (경성대학교 약학대학) ;
  • 최종원 (경성대학교 약학대학)
  • Published : 1996.02.01

Abstract

The present study was undertaken to investigate the effect of the water extract of the puffer fish Fugu xanthopterus(FXH) on the alcohol induced hyperuricemia. The normal group and the FXH treated group showed no sigbificant changes in the levels of blood uric acid but, the blood uric acid significantly decreased in the FXh treated rats with 100mg/kg for two weeks compared to the ethanol treated group. There were no significant changes in the activities of uricase, adenosine deaminase, guanine deaminase, and purine uncleoside phosphorylase, among all the test group. But the activitis of liver xanthine oxidase were recovered to the normal level in ethanol +FXH treated group comparing to the ethanol treated group. Furthermore, ethanol+FXH treated rats showed the similar pattern in the levels of blood uric acid and urinary allantoin with normal group. These results indicate that the decreased blood uric acid by the FXH treatment of the alcohol induced hyperuricemia rats may result from decreased activity of hepatic xanthine oxidase.

References

  1. Annu. Rev. Biochem. v.40 The biological significance of purine salvage Murray, A. W.
  2. Arthritis Rheum. v.18 Proceeding of the second conference on gout and purine metabolism Hinenberg, T. R.
  3. 의약정보 v.140 통풍과 고요산혈증 곽재욱
  4. 임상약학 v.115 통풍의 유전 유대현
  5. 의약정보 v.201 통풍의 정의와 병태생리 김호연
  6. 한국영양식량학회지 v.23 Alcohol 섭취 쥐에서 alcohol 대사효소계에 미치는 복어추출물의 효과 김동훈;김동수;최종원
  7. 한국영양식량학회지 v.23 흰쥐에서 acetaldehyde대사에 미치는 복어추출물의 영향 김동훈;김동수;최종원
  8. J. Gen. Physiol. v.78 Tetrodotoxin block of sodium channels in rabbit Punkinje fibers Cohen, C. J.;Bean, B. P.;Colatsky, T. J.;Tsien, R. W.
  9. J. Mol. Cell. Cardiol. v.16 Block of avian cardiac fast sodium channels by tetrodotoxin is enhanced by repetitive depolarization but not by steady depolarization Inoue, D.;Pappano, A. J.
  10. Proc. West. Pharmacol. Soc. v.28 Is tetrodotoxin block cardiac sodium channels voltage dependent Hongeghem, L. M.;Clarkson, C. W.;matsubara, I.
  11. Acta Physiologica Hungarica v.73 Frequency-dependent and independent effects of tetrodotoxin on Vmax in cardiac fibers Varro, A.;Nakaya, Y.;Elharrar, V.;Surawicz, B.
  12. Arch. Pharmacol. v.314 Effects of tocainide and lidocaine on the transmembrane action potentials as related to external potassium and calcium concentrations in guinea pig capillary muscles Oshita, S.;Sada, H.;Kojima, M.;Ban, T.
  13. Bull. Japan Soc. Sci. Fisher. v.35 Occurrence of ciguotoxin and ciguaretin in ciguatoxic fishea in the Ryukyu and Amami island Hashimoto, Y.;Yasumoto, T.;Kamiya, H.;Yoshida, T.
  14. Biochem. Pharmacol. v.24 Effects of ethanol on hepatic drug-metabolizing enzymes in the rat Liu, S. J.;Ramsey, R. K.;Fallon, H. J.
  15. Uric acid assay, committee on continuing education Bittner, D. H.;Gambino, S. R.
  16. Clin. Chem. Acta v.43 Determination of serum creatinine by a direct colorimetric method Heinegard, D.;Tiderstrom, G.
  17. Anal. Biochem. v.79 Allantoin determination Borchers, R.
  18. The enzymes v.8 Mahler, H. R.;Boyer, P. D.;Lardy, H. A.;Myrback, K.
  19. Methods Enzymol. v.51 Purine nucleoside phosphorylase from rabbit liver Glantz, H.;Lewis, A. S.
  20. Science v.182 Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells : role of adenosine deaminase Green, H.;Chan, T.
  21. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase. Conversion in vitor of the enzyme activity from dehydrogenase(Type D) to oxidase(Type O) Stripe, F.;Della Corte, E.
  22. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O. H.;Rosebrough, N. J.;Farr, A. L.;Rendall, R. J.
  23. 인삼패독산이 microcrystalline sodium ureate로 유발된 흰쥐의 통풍에 미치는 영향 김태희
  24. 대한침구학회지 v.11 위영선수침이 통풍유발 흰쥐의 병리적 소견에 미치는 영향 장현석
  25. Biochem. Pharmacol. v.36 Enhancement of hypoxicliver damage by ethanol. Involvement of xanthine oxidase and the role of glycolysis Younes, M.;Strubelt, O.
  26. Gastroenterology v.94 Ethanol induced lipid peroxidation is inhibited by allopurinol and may result from increased NADH and purine degradation Kato, S.;Anderman, J.;Kawase, T.;Lieber, C. S.
  27. Cancer. Res. v.23 Relationship between metabolic fates and antitumor activities of thiopurines Elion, G. B.;Callahan, S.;Rundles, R. W.;Hitchigs, G. H.
  28. J. Lab. Clin. Med. v.66 Xanthine oxidase activity in human tissues and its inhibition by allopurinol Watts, R. W. E.;Watts, J. E. M.;Seegmiller, J. E.
  29. J. Clin. Invest. v.41 Interrelation of uric acid and ethanol metabolism in man Lieber, C. S.;Jones, D. P.;Losowsky, M. S.;Davidson, C. S.
  30. J. Clin. Invest. v.74 Ethanol-induced activation of adenine nucleotide turnover. Evidence for the role of acetate Puig, J. C.;Fox, I. H.
  31. Biochemistry v.15 Bovine brain purinenucleoside phosphorylase purification, characterization and catalytic mechanism Lewis, A. S.;Glantz, M. D.
  32. Anal. Biochem. v.146 Stimultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotide in human red blood cells Stocchi, V.;Gucchiarini, L.;Magnani, M.;Chiarantini, L.;Palma, P.
  33. Biochem. Biophys. Res. Commun. v.141 Absorbance of xanthine oxidase and xanthine dehydrogenase in the rabbit myocardium Grum, C. M.;Ragsdale, R. A.;Ketai, L. H.;Shlafer, M.
  34. Uric acid. Handbuch det Experimentellen Pharmakologie v.51 Allopurinol and other inhibitors of ureate synthesis Elion, G. B.
  35. Bull. Rheum. Dis. v.32 Treatment of the gout and other forms of crystal-induced arthritis Rodnan, G. P.