Study on the synthesis and Antimicrobial activity of 5.7-Dibromo-8-hydroxyquinolinyl-N-ethylcarbamate

5.7-Dibromo-8-hydroxyquinolinyl-N-ethylcarbamate의 합성및 항균작용에 관한 연구

  • 강회양 (계명대학교 자연과학대학 공중보건학과) ;
  • 민경진 (계명대학교 자연과학대학 공중보건학과)
  • Published : 1996.03.01

Abstract

5.7-Dibromo-8-hydroxyquinolinyl-N-ethylcarbamate, one of the carbamate derivative which are generally used as insecticide, was newly synthesized. Its physical properities were determined and chemical structure was identified by means of I.R., nmr in addition to elemental analysis. The yield of addition, using triethylamine as catalyst, 5.7-dibromo-8-hydroxyquinoline and isocyanate was better than that of condensation of 5.7-dibromo-8-hydroxyquinoline with carbamoylchloride. The present organic synthesized compound showed the bacteriostatic action on salmonella typhi, escherichia coli and pseudomonas aeruginosa, but no otherwise effect of contraction of rabbit's ileum in the concentration of $100 \mu g/ml$.