Determination of Cd and Pb in Human Blood by Isotope Dilution Inductively Coupled Plasma Mass Spectrometry : International Comparison

동위원소희석 질량분석법에 의한 혈액 중 Cd, Pb 성분의 측정 : 국제공동분석

  • Park, C.J. (Inorganic Analytical Laboratory, Korea Research Institute of Standards and Science) ;
  • Suh, J.K. (Inorganic Analytical Laboratory, Korea Research Institute of Standards and Science) ;
  • Lee, S.H. (Inorganic Analytical Laboratory, Korea Research Institute of Standards and Science)
  • 박창준 (한국표준과학연구원 무기분석그룹) ;
  • 서정기 (한국표준과학연구원 무기분석그룹) ;
  • 이상화 (한국표준과학연구원 무기분석그룹)
  • Received : 1996.03.08
  • Published : 1996.06.25

Abstract

Inorganic analytical laboratory of Korea Research Institute of Standards and Science participated in an interlaboratory comparison program operated by Quebec Toxicology Centre of Canada in 1994 and again in 1995. The objective of this program is to enable participating laboratories to assess reproducibility and accuracy of their analytical results for trace toxic elements in human biological fluids. This laboratory determined Cd and Pb concentrations in 3 levels of human blood samples by isotope dilution inductively coupled plasma mass spectrometry. 0.5mL of blood sample is added to the digestion bomb together with 2mL of nitric acid and enriched spike isotopes and then decomposed in the microwave digestion system. The decomposed sample is diluted to 10mL and nebulized into ICP-MS. The Cd and Pb values reported by all participating laboratories are presented and compared. The values reported by this laboratory are within the acceptable range of target values.