Haptoglobin as an early indicator of infection in pigs

돼지에서 감염의 조기진단 지표로서의 Haptoglobin 적용에 관한 연구

  • 문진산 (농촌진흥청 수의과학연구소) ;
  • 남향미 (농촌진흥청 수의과학연구소) ;
  • 구복경 (농촌진흥청 수의과학연구소) ;
  • 주이석 (농촌진흥청 수의과학연구소) ;
  • 정석찬 (농촌진흥청 수의과학연구소) ;
  • 김종염 (농촌진흥청 수의과학연구소) ;
  • 박용호 (서울대학교 수의과대학)
  • Received : 1996.01.29
  • Published : 1996.09.25


Sera of pigs with clinically normal and infectious conditions were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) to demonstrate the specific changes in protein profile. In the sera from pigs with infection, haptoglobin with a 40KDa protein was found to be increased as compared to that of sera from normal pigs. As a rapid detection method for monitoring infections at large-scale farms, one of acute phase protein, haptoglobin, was selected to compare the concentrations between infectious and non-infectious conditions. Haptoglobin concentrations were low in pigs with clinically normal conditions but significantly increased in pigs with Aujesky's disease, hog cholera and parvo-virus infection. The studies provide that haptoglobin can be used as an indicator to monitor infections early at farm level.