Neuromodulation on neurogenic contraction of electrical nerve stimulation on isolated renal artery of rabbit

토끼 적출 신동맥에 있어서 전기자극에 의한 신경성 수축작용의 neuromodulation 효과

  • Kim, Joo-heon (College Veterinary Medicine, Gyeongsang National University) ;
  • Hong, Yong-geun (College Veterinary Medicine, Gyeongsang National University)
  • 김주헌 (경상대학교 수의과대학) ;
  • 홍용근 (경상대학교 수의과대학)
  • Received : 1996.10.04
  • Published : 1996.12.25

Abstract

To elucidate the neuromodulation of neuropeptide Y and $\alpha,\;\beta$-methylene ATP on the neurogenic contraction of electrical perivascular nerve stimulation and the contractile response of noradrenaline from polygraph in the isolated renal artery of rabbit. 1. The neurogenic contraction induced by perivascular nerve stimulation was the voltage-dependent manner(10-100V) in the isolated renal artery of rabbit. 2. Neuropeptide Y(0.1uM) and $\alpha,\;\beta$-methylene ATP(1uM) increased the contractile responses of noradrenaline in the isolated renal artery of rabbit. 3. Neuropeptide Y(0.1uM) and $\alpha,\;\beta$-methylene ATP(1uM) increased the neurogenic contraction of electrical perivascular nerve stimulation in the isolated renal artery of rabbit. These results suggest that neuropeptide Y and $\alpha,\;\beta$-methylene ATP neuromodulated on the neurogenic contraction of electrical perivascular nerve stimulation on the isolated renal artery of rabbit.

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Acknowledgement

Supported by : 한국학술진흥재단