Evaluation of Hepatoprotective Potential of Cassia tora Leaf Extract

  • Maity, Tapan Kumar (College of Pharmaceutical Sciences At and P.O. -Mohuda, Berhampur, Dist.-Ganjam) ;
  • Mandal, Subhash C. (Department of Pharmaceutical Technology Faculty of Engineering and Technology Jadavpur University) ;
  • Mukherjee, Pulok K. (Department of Pharmaceutical Technology Faculty of Engineering and Technology Jadavpur University) ;
  • Saha, Kakali (Department of Pharmaceutical Technology Faculty of Engineering and Technology Jadavpur University) ;
  • Das, J. (University College of Medicine, University of Calcutta) ;
  • Saha, B.P. (Department of Pharmaceutical Technology Faculty of Engineering and Technology Jadavpur University) ;
  • Pal, M. (Department of Pharmaceutical Technology Faculty of Engineering and Technology Jadavpur University)
  • Published : 1997.12.01

Abstract

Methanolic extract of the leaves of Cassia tom was evaluated for its hepatoprotective potentials in rats by inducing hepatotoxicity with carbon tetrachloride. The extract at a dose of 400 mg/kg orally showed significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). The effects produced were comparable to that of a standard hepatoprotective agent.

Keywords

Cassia tora;methanolic extract;SGOT;SGPT;ALP;Bilirubin;$CCI_4$;hepatic damage