Inhibition Effect of ACE (Angiotensin Converting Enzyme) and Kinetics of Aloe Acethylmannan

알로에 아세칠만난의 ACE (Angiotensin Converting Enzyme) 저해효과 및 동력학적 분석

  • Ryu, Il-Whan (R & D Center, Kim Jeong Moon Aloe Co., Ltd.) ;
  • Shin, Yong-Seo (The Graduate School of Biotechnology, Korea University)
  • 류일환 (김정문 알로에 과학연구소) ;
  • 신용서 (고려대학교 생명공학원)
  • Published : 1997.12.01

Abstract

This study was researched to purify and characterize variety bioactive material acethylmannan from Aloe vera. Purified acethylmannan was mannose (67%), acetyl group (23%) and the rest glucose, galactose that consisting of long chain polydispered ${\beta}-1,4$ linked mannan polymers. The sugar and acetyl group in molecular were linked molar ration one third. $IC_{50}$ value (i.e that concentration which exhibits 50% more enzyme inhibition than control) on angiotensin converting enzyme were 0.58 mM. This compound were found to be a competitive inhibition of Angiotensin Converting Enzyme with apparent Ki values of 0.068 mM.