Antimutagenic Effects of Methyl Alcohol Extracts from Auricularia auricula and Gyrophora esculenta

목이 및 석이 메틸 알콜 추출물의 항돌연변이원성

  • Ham, Seung-Shi (Division of Food and Biotechnology, Kangwon National University) ;
  • Kim, Deug-Ha (Sannaedle Research Institute) ;
  • Lee, Deuk-Sik (Division of Food and Biotechnology, Kangwon National University)
  • 함승시 (강원대학교 식품생명공학부) ;
  • 김득하 (산내들 기술연구소) ;
  • 이득식 (강원대학교 식품생명공학부)
  • Published : 1997.12.01

Abstract

This study was conducted to investigate the antimutagenic effects of methyl alcohol extracts from Auricularia auricula and Gyrophora esculenta on the SOS response induced by 4-nitroquinoline-1-oxide (4NQO), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), mitomycin C (MMC) and 3-amino-1,4- dimethyl-5H-pyrido-[4,3-b]indol (Trp-P-1) in E. coli PQ37/plasmid pKM101. In the mutagenic test on test strain, both methyl alcohol extracts did not show mutagenic activity. In the antimutagenic test, each sample strongly inhibited the mutagenecity induced by 4NQO, MNNG, MMC and Trp-P-1. Methyl alcohol extracts from Auricularia auricula and Gyrophora esculenta showed inhibitory effects of 52% and 59% against 4NQO, 49% and 58% against MNNG, 53% and 64% against MMC, and 61% and 64% against Trp-P-1, respectively. Gyrophora esculenta extracts on the antimutagenicity showed relatively higher inhibitory effects than that of Auricularia auricula.