Effect of Hot Water Extracts from Medicinal Plants on the Mutagenicity of Indirect Mutagens

간접변이원의 돌연변이원성에 대한 생약재 열수 추출물의 효과

  • Song, Geun-Seoub (Department of Food Engineering, Iri National College of Agriculure & Technology) ;
  • Ahn, Byung-Yong (Division of Life Science and Natural Resource, Wonkwang University) ;
  • Lee, Kap-Sang (Division of Life Science and Natural Resource, Wonkwang University) ;
  • Maeng, Il-Kyung (Department of Food Science and Technology, Chonbuk National University) ;
  • Choi, Dong-Seong (Division of Food, Environmental and Chemical Engineering and Biotechnology, Woosuk University)
  • 송근섭 (이리농공전문대학 식품공업과) ;
  • 안병용 (원광대학교 생명자원과학대학) ;
  • 이갑상 (원광대학교 생명자원과학대학) ;
  • 맹일경 (전북대학교 식품공학과) ;
  • 최동성 (우석대학교 생물식품 및 환경화공학부)
  • Published : 1997.12.01

Abstract

For screening antimutagenic effects, the effects of 95 medicinal plants on the mutagenicity of aflatoxin $B_1$ $(AFB_1)$ and benzo(a)pyrene [B(a)P] were investigated using the SOS chromotest with Escherichia coli PQ37. The mutagenicity induced by $AFB_1$ or B(a)P was reduced over 26% by 2 kinds and 8 kinds of medicinal plant, respectively. Eight plants (Bupleurum falcatum, Corydalis ternata, Gasfrodia elata, Ostericum koreanum, Pinellia ternatia, Poncirus trifoliata, Prunus armeniaca and Rehmannia glutinosa) were also shown to have inhibitory effects on both $AFB_1$ and B(a)P. The mutagenicity induced by $AFB_1$ or B(a)P was increased over 20% by 46 kinds and 2 kinds, respectively, and 8 medicinal plants (Chrysanthemum indicum, Cinnamomum cassia, Cyperus rotundus, Morus bombycis, Patrinia scabiosaefolia, Petasites japonicus, Polygonum multiflorium, Thyja orientalis) increased significantly the mutagenicity of both mutagens. However the 8 plants themself did not show the mutagenicity in SOS Chromotest with S-9 mix alone. This result suggests that the above 8 plants may have the co-mutagenic activities. In two bacterial mutation system, SOS Chromotest and Ames test, the mutagenic or antimutagenic activities of some medicinal plants wire similar except Ostricum koreanum, Eugenia caryophyllata and Scutellaria baicalensis.

Keywords

antimutagenic effects;medicinal plants;aflatoxin $B_1$;benzo(a)pyrene;SOS Chromotest