CD44 Expression in Healing Nd:YAG Laser Wounds and Scalpel Incisions of the Rat Tongue Mucosa

Nd: YAG 레이져와 수술칼로 절개한 흰쥐 혀점막에서의 CD44 발현

  • 박미희 (부산대학교 치과대학 구강내과학교실) ;
  • 박준상 (부산대학교 치과대학 구강내과학교) ;
  • 고명연 (부산대학교 치과대학 구강내과학교) ;
  • 박봉수 (부산대학교 치과대학 구강해부학교실)
  • Published : 1997.06.01


This study was undertaken to compare and investigate the wound healing process following Nd:YAG laser wounds and scalpel incisions of the rat tongue dorsal mucosa. Laser wounds were made parallel on the right side of tongue dorsum and scalpel incisions were made on the left side with 5mm length, respectively Visual inspection and immunohistochemistry with CD44 antibody after immediately, 6 hours, 1 day, 2, 4, 7, 11, 21 days after surgery were carried out. The results were as follows : 1. There was macroscopically no treat difference between laser wounds and scalpel incisions. 2. Laser wounds appeared as dry, bloodless and irregular grooves with carbonization and whitening of superficial tissues compared to sharp, straight and bleeding incisions using scalpel. 3. In the epithelium of rat tongue mucosa, CD44 expression in healing laser wounds and scalpel incisions were similar. 4. In the lamina propria and muscle layer, CD44 expression in healing laser wounds gradually increased earlier and decreased faster than scalpel incisions. Conclusively, it is suggested that pulsed Nd:YAG laser has more beneficial effect on the healing of wounded oral mucosa than scalpel in knew of CD44 expression.