Induction of Hepatic Glutathione S-transferase Activity in Mice Administered with Various Vegetable Extracts

  • Kim, Mee-Ree (Dept. of Food and Nutrition, Chungnam National University) ;
  • Lee, Kun-Jong (Dept. of Food and Nutrition, Chungnam National University) ;
  • Kim, Yun-Bae (Agency for Defense Machine Depot) ;
  • Sok, Dai-Eun (College of Pharmacy, Chungnam National Universty)
  • Published : 1997.09.01

Abstract

The effect of various vegetables commonly consumed by Koreans on the induction of glutathione S-trasferase(GST) activity in mice was assessd. The extract of vegetable dissolved in propylene glycol (5ml/kg body wt.) was administered to ICR female mice 6 to 8 weeks old via gavage during 5 days. The changes of body weight and liver weight of all treated groups were not significantly different compared with control group. Hepatic protein contents of trated groups compared with control group were not significantly different except BHT treated group. The induction of GST activity in liver cytosol of mice was the greatest with broccoli, followed by radish, wild green onion, turnip, and green onion. The induction of GST activity in liver cytosol increased up to 1.5 to 1.8-folds at a dose of 24 g fresh vegetable/mouse. The induction of combination between vegetables was the highest with the combination of broccoli and radish (1.83-fold), followed by that of broccoli and green onion (1.72-fold), and that of broccoli and turnip (1.50-fold).