Effects of Different Sources of Dietary n-3 Fatty Acids on Immune Response and Eicosanoids Production

급원이 다른 n-3 지방산이 흰쥐에서 면역반응과 Prostaglandin $E_2$ 및 Leukotriene $B_4$ 생성에 미치는 영향

  • Published : 1997.08.01

Abstract

This study was planned to compare the effects of source of dietary n-3 fatty acids, i.e., tuna oil and perilla oil, on mitogenesis and production of prostaglandin E$_2$ and leukotriene B$_4$ in rats. Weaning male Sprague-Dawley rats were fed 3 different experimental diets for 4 weeks(Control: beef tallow 50% + sesame oil 50%, FO : beef tallow 50% + sesame oil 25% + tuna oil(27% docosahexaenoic acid) 25%, PO : beef tallow 50% + sesame oil 25% + perilla oil 25%). Food intakes were higher in FO group than in other groups, but body weight gains, food efficiency rates and weights of spleen were not different among groups. Proliferation of splenocyte to PWM(pokeweedmitogen) was higher in FO and PO group than control group. But there was no difference between FO and PO group. Response to ConA was not different among three groups. Serum PGE$_2$ levels were higher in control group than other groups. Serum LKB$_4$ levels were not different among groups. Therefore, it seemed that n-3 fatty acids increased the immune response by means of decreasing the PGE$_2$ production.

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