Effect of cadmium on immune responses and enzyme activities in BALB/c mice 3. Enzyme activities

카드뮴이 BALB/c 마우스의 면역반응 및 효소활성에 미치는 영향 3. 효소활성

  • 윤창용 (국립식품의약품 안전본부 세균제제과) ;
  • 김태중 (전북대학교 생체안전성연구소) ;
  • 조정곤 (전북대학교 생체안전성연구소) ;
  • 송희종 (전북대학교 생체안전성연구소)
  • Received : 1997.02.27
  • Published : 1997.06.25

Abstract

This study was designed to investigate the effects of varying concentrations of $CdCl_2$ on the enzyme activities such as LDH and SOD related with the accumulations of cadmium(Cd) in liver and kidney of BALB/c mice. 1. Cd accumulations in liver and kidey were increased in a dose dependent fashion. And also, this pattern was more conspicuous in kidney than that in liver. 2. LDH activities of liver and kidney were increased in a dose dependent fashion except for that of liver in 200 ppm Cd group which was similar to that of 25 ppm Cd group. 3. SOD activities of Cd exposed liver and kidney in Cd-fed mice similar to those of controls except for elevation of SOD activity of liver in 25 ppm Cd group. The results of this study suggest that the activities of various enzymes can be modulated by Cd intoxication. Acknowledgement: This study was financially supported in part by a Research Grant from Bio-Safty Research Institute, Chonbuk National University in 1997(CNU-BSRI, No. 97-03).