Effect of Platycodon grandiflorum DC Extract on the Growth of Cancer Cell Lines

도라지(Platycodon grandiflorum DC) 추출 성분의 암세포 증식 억제효과

  • Lee, Ji-Young (Graduate School of Natural Resources, and Center for Advanced Food Science and Technology, Korea University) ;
  • Hwang, Woo-Ik (Department of Biochemistry, Medical College, Korea University) ;
  • Lim, Seung-Taik (Graduate School of Natural Resources, and Center for Advanced Food Science and Technology, Korea University)
  • 이지영 (고려대학교 자연자원대학원,식품가공핵심기술연구센터) ;
  • 황우익 (고려대학교 의과대학 생화학교실) ;
  • 임승택 (고려대학교 자연자원대학원,식품가공핵심기술연구센터)
  • Published : 1998.02.01

Abstract

To investigate the cytotoxic effect of Platycodon grandiflorum DC, petroleum ether extract of Platycodon grandiflorum DC was partially purified by a silica gel column chromatography. Among several fractions, fraction D which was obtained under the elution with a 7:3 mixture of petroleum ether and ethyl ether, showed patent cytotoxicity against mouse leukemia cell line (L1210), human rectum cancer cell line (HRT-18) and human colon cancer cell lint (HCT-48).

Keywords

antitumor activity;Platycodon grandiflorum DC;petroleum ether extract