Effects of Godulbaegi Extracts on the Stability and Fluidity of Phospholipid Liposomal Membranes

고들빼기 추출물이 인지질막 Liposome의 안정성 및 유동성에 미치는 영향

  • 배송자 (신라대학교 식품영양학과) ;
  • 노승배 (양산전문대학 식품영양과) ;
  • 정복미 (여수대학교 식품영양학과)
  • Published : 1998.06.01

Abstract

We investigated the effects of godulbaegi extracts on the physiochemical properties of biological membranes as membrane stability and fluidity employing the phospholipid liposomal membrances as a biomembrane-mimetic system. The addition of the godulbaegi extracts to the phospholipid exterted great effects stagbilized the barrier function of the liposomal membranes in proportion to the concentration of the additive and significantly increased the membranes fluidity. The values of the fluorescence polarization of 1,6-diphenyl 1,3,5-hexatriene (DPH) decreased gradually as the temperature increased, and decreased abruptly near the phase transition temperature (Tm) of the liposome from gel to liquid crystalline state as usual. These results suggest that the activities of the godulbaegi extracts to enhance the stability and fluidity of the liposomal membranes have implication in their biological activities.

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