Inhibitory Effect of Angelica keiskei Koidz Green Juice on the Liver Damage in CCl4-Treated Rats

신선초 녹즙이 사염화탄소 투여에 의한 흰쥐의 간 손상에 미치는 영향

  • 이명렬 (조선대학교 식품영양학과) ;
  • 정희경 (조선대학교 식품영양학과) ;
  • 박평심 (조선대학교 식품영양학과) ;
  • 허남칠 (조선대학교 식품영양학과) ;
  • 김성오 (동신전문대학 환경위생과) ;
  • 김경수 (조선대학교 식품영양학과)
  • Published : 1998.06.01

Abstract

To investigate effects of Angelica keiskei Koidz green juice on the liver damage of CCl4-treated tats, Sprague-Dawley male rats weighing 80~100g were divided into 4 groups of control group(CON), Angelica keiskei Koidz green juice-treated group(ANJ), CCl4-treated group(CCL) and Angelica keiskei Kodiz green juice and CCl4-treated group(ACL). Each group was sacrified after feeding for 4 weeks and examined the activities of transminase (sGOT, sGPT), superoxide dismutase (SOD), catalase and glutathione peroxidase(GSH-Px), and contents of lipid peroxide and glutathione in liver. The activities of sGOT and sGPT, and content of lipid peroxide after CCl4 treatment were markedly increased, compared to CON, but those levels were significantly decreased by the pretreatment of Angelica keiskei Koidz green juice as compared to CCL. The activities of SOD, catalase and GSH-Px were elevated by CCl4-treatment as compared to control group, and concomitant treatment of Angelical keiskei Koidz and CCl4 decreased those levels significantly except the activity of catalase. The hepatic content of glutathione was decreased by CCl4 and increased more abundant by Angelica keiskei Koidz administration than CCl4 treated group. These results suggest that Angelica keiskei Koidz green juice is believed to have a possible protective effect for the carbon tetrachloride-induced hepatotoxicity in rats.

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