A Facile Synthesis of Ethyl 2,6-Di-O-benzyl-3-O-(3,4,6-tri-O-acetyl-2-deoxy-2-N-phthalimido-$\beta$-D-glucopyranosyl)-1-thio-$\beta$-D-galactopyranoside and Studies on the Regioselectivity of 2,3,4-OH Groups of Galactosyl Acceptor

Ethyl 2,6-Di-O-benzyl-3-O-(3,4,6-tri-O-acetyl-2-deoxy-2-N-phthalimido-$\beta$-D-glucopyranosyl)-1-thio-$\beta$-D-galactopyranoside의 합성법의 개발 및 갈락토스 받게의 2,3,4-OH기들의 위치 선택성에 대한 연구

  • Published : 19981000

Abstract

O-Antigenic part of Campylobacter jejuni gram negative bacteria was reported to consist of a repeated trisaccharide unit. The disaccharides, GlcNAc-Gal derivatives, as key intermediates for the synthesis of trisaccharide repeating units were synthesized. At the $\beta(1{\to}3)$ glycoside bond formation step between 3,4,6-tri-O-acctyl-2-deoxy-2-N-phthalimido-${\beta}$-D-glucopyranosyl bromide and galactosyl acceptors, high regioselectivities between 2, 3, and 4-OH groups of galactosyl acceptors were found. As a result, no further selective protection steps for OH groups of galactosyl acceptors was necessary, and more effective and compact synthetic scheme was achieved.

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