Synthesis and Biological Evaluation of Novel 2-[Substituted acetly]-amino-5-alkyl]-amino-5-alkyl-1,3,4-thiadiazoles

  • Shakya, Ashok K. (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
  • Mishra, Pradeep (Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya [Formerly University of Saugor]) ;
  • Patnaik, G.K. (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
  • Shukla, Rakesh (Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories) ;
  • Srimal, R.C. (Division of Pharmacology Central Drug Research Institute)
  • Published : 1998.12.01

Abstract

Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazol were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significan non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90mg/kg p.o. was two fold higher compared to 50mg/kg p.o. of furosemide. Comparable diuresis was aso produced by compounds 9, 10, and 16.