Inhibition of Nitric Oxide Synthesis by 8-epi-xanthatin in Activated RAW 264.7 Cells

활성화한 RAW 264.7 세포주에서 8-epi-xanthatin의 Nitric Oxide 생성저해

  • Lee, Hwa-Jin (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Women's University) ;
  • Jeong, Yeon-Su (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Women's University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Ryu, Jae-Ha (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Women's University)
  • 이화진 (숙명여자대학교 약학대학 약학연구소) ;
  • 정연수 (숙명여자대학교 약학대학 약학연구소) ;
  • 류시용 (한국화학연구소) ;
  • 류재하 (숙명여자대학교 약학대학 약학연구소)
  • Published : 1998.10.01

Abstract

The nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase is known to be responsible for the vasodilation and hypotension observed in septic shock. We have found that 8-epi-xanthatin from Xanthium strumarium L. inhibited the production of NO in LPS-activated RAW 264.7 cells ($IC_{50}$ value was 1.5 ${\mu}$M). This activity was resulted from the suppressing of inducible nitric oxide synthase enzyme expression.

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