Metabolic aspects of the toxicology of mixtures of diazinon, toxaphene and/or endrin in mice

마우스에서 diazinon, toxaphene 과 endrin 단독 혹은 그 혼합물 독성의 대사

  • Kim, Jong-shu (College of Veterinary Medicine, Gyeongsang National University(Inst. of Animal Medicine)) ;
  • Kim, Gon-sup (College of Veterinary Medicine, Gyeongsang National University(Inst. of Animal Medicine)) ;
  • Hah, Dae-sik (Gyeongnam Provinical Government Institute of Health and Environment)
  • 김종수 (경상대학교 수의과대학 부속 동물의학연구소) ;
  • 김곤섭 (경상대학교 수의과대학 부속 동물의학연구소) ;
  • 하대식 (경남보건환경연구원)
  • Received : 1998.01.30
  • Published : 1998.06.25


The effects of mixtures of diazinon(DA;5mg/kg), toxaphene(TOX;40mg/kg) and/or endrin(END; 5mg/kg) on the hepatic mixed-function oxygenase(MFO) system were stuided in ICR mice(18~22g) by oral intubation daily for 7 days. In general, TOX and TOX-containing mixtures were found to induced the metabolism of aminopyrine(22~60%), aniline(42~85%), phenacetin(145~194%) and benzo [a]pyrene(158~210%), and pentobaribtal biotransformation in the 9,000g liver supernatants and to increased the hepatic cytochrome p-450 contents(47~89%). Results of these may be, at least in part, associated with the MFO system. TOX pretreatment increased the aliesterase activity in the serum and liver homogenates and supernatants by 23~145%. The toxicity of TOX and TOX-containing mixtures would be lower than that of diazinon because of TOX-induced increase in the metabolism of diazinon(DA) or diazioxon(DO) and capability of TOX to stimulate the metabolism of diazinon and diazioxon and provide a pool of non-critical enzymes. These results suggest that this information might be helpful in the evaluation of the potential hazard due to occupational and/or environmental exposures to pesticides and their mixtures.